منابع مشابه
Spindle microtubules in flux.
Accurate and timely chromosome segregation is a task performed within meiotic and mitotic cells by a specialized force-generating structure--the spindle. This micromachine is constructed from numerous proteins, most notably the filamentous microtubules that form a structural framework for the spindle and also transmit forces through it. Poleward flux is an evolutionarily conserved mechanism use...
متن کاملSpindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins
The kinetochore forms a dynamic interface with microtubules from the mitotic spindle. Live-cell light microscopy-based observations on the dynamic structural changes within the kinetochore suggest that molecular rearrangements within the kinetochore occur upon microtubule interaction. However, the source of these rearrangements is still unclear. In this paper, we analyze vertebrate kinetochore ...
متن کاملMicrotubules park parallel in the half-spindle
y the late 1970s, it was still unclear how microtubules (MTs) operated in the mitotic spindle. Several pieces of the microtubule puzzle had been worked out: micro-tubules slid past each other to give cilia their movement (Satir, 1968); dynein cross-bridges linked MTs together (Gibbons, 1966); and MT polymers had polarity. That polarity was reflected by both the orientation of asymmetric subunit...
متن کاملRINGO C is required to sustain the spindle-assembly checkpoint.
RINGO/Speedy proteins are direct activators of Cdk1 and Cdk2 that have no sequence homology to cyclins. We have characterized the role in cell-cycle progression of a new human member of this protein family referred to as RINGO C. We show that siRNA-mediated knockdown of RINGO C results in premature mitotic exit with misaligned chromosomes, even in the presence of microtubule poisons. Time-lapse...
متن کاملReleasing the spindle assembly checkpoint without tension
Eukaryotic cells have evolved a spindle assembly checkpoint (SAC) that facilitates accurate genomic segregation during mitosis by delaying anaphase onset in response to errors in kinetochore microtubule attachment. In contrast to the well-studied molecular mechanism by which the SAC blocks anaphase onset, the events triggering SAC release are poorly understood. Papers in this issue by Uchida et...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2014
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2053iti1